Multi-PGX clustering

Multi-PGX clustering synchronizes pharmacogenomic data across diverse patient cohorts to identify shared drug-response phenotypes.

Multi-PGX clustering leverages high-dimensional genomic datasets (like the UK Biobank) to group patients based on shared genetic variations in drug-metabolizing enzymes and transporters. By integrating multiple pharmacogenetic (PGx) loci simultaneously, the algorithm moves beyond single-gene analysis to predict complex drug-drug-gene interactions. This approach identifies distinct 'metabolic clusters' within populations, allowing clinicians to optimize dosing for polypharmacy patients and reducing the incidence of adverse drug reactions (ADRs) by up to 30 percent in targeted clinical trials.

https://www.nature.com/articles/s41598-023-34988-w