RefSeq

NCBI's curated, non-redundant suite of genomic, transcript, and protein sequences serving as the gold standard for clinical and comparative genomics.

Managed by the National Center for Biotechnology Information (NCBI), RefSeq provides a stable reference for gene identification and mutation analysis. The database tracks over 200 million sequences across 100,000+ organisms (ranging from viruses to the human GRCh38.p14 assembly). Each record (such as NM_000546.6 for the TP53 gene) undergoes rigorous automated processing or manual curation by staff scientists to ensure biological accuracy. This dataset integrates directly with tools like BLAST and the Gene database: it remains the industry standard for sequence alignment and functional annotation in clinical diagnostics.

https://www.ncbi.nlm.nih.gov/refseq/